HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)phenylboronic acid → (rac)-7-Methyl-4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| Reactant | 4-Bromo-7-methyl-6,7-dihydro-5H-cyclopenta[C]pyridin-7-OL | HCID 89846349 | — |
| Product | (rac)-7-Methyl-4-(4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol | HCID 71760914 | 85% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1 (rac)-4-bromo-7-methyl-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ol (intermediate A-13) was reacted with 4-(trifluoromethyl)phenylboronic acid to give the title compound as grey solid in 85% yield. MS: 294.1 (M+H+)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-7ae263d45c8f4505bae8462e6aa9a88d |
| Source note | uspto-grants-2015_11 |