(rac)-4-(3-Fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-ylamine → (rac)-4-(4-Trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-ylamine

Participants

Reaction Steps

In analogy to the procedure described for the preparation of (rac)-4-(3-fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-ylamine (example 89), replacing 4-(3-fluoro-4-trifluoromethyl-phenyl)-5,6-dihydro-[2]pyrindin-7-one with 4-(4-trifluoromethyl-phenyl)-5,6-dihydro-[2]pyrindin-7-one (intermediate A-15). The title compound was obtained as a light brown oil in 49% yield. MS: 279.5 (M+H)+.

Provenance & Evidence