HuagongsheHuagongshe Chemistry Print Report · For research reference only
(rac)-Cyclopropanesulfonic acid [4-(3-fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-yl]-amide → (rac)-Cyclopropanesulfonic acid [4-(4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (rac)-Cyclopropanesulfonic acid [4-(3-fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-yl]-amide | HCID 71811527 | — |
| Reactant | (rac)-4-(4-Trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-ylamine | HCID 89846378 | — |
| Product | (rac)-Cyclopropanesulfonic acid [4-(4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-yl]-amide | HCID 71811494 | 4% |
Reaction Steps
In analogy to the procedure described for the preparation of (rac)-cyclopropanesulfonic acid [4-(3-fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-yl]-amide (example 91), replacing (rac)-4-(3-fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-ylamine with (rac)-4-(4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-ylamine (example 93). The title compound was obtained as a light brown oil in 4% yield. MS: 383.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-a0a9fb8dc60c403185435d7cf7c90c17 |
| Source note | uspto-grants-2015_11 |