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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 714103Generated: October 30, 2026

Methanesulfonyl chloride → (rac)-N-[4-(4-Trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-yl]-methanesulfonamide

https://huagongshe.com/reaction/714103

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanesulfonyl chlorideHCID 31297—
Reactant(rac)-Cyclopropanesulfonic acid [4-(4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-yl]-amideHCID 71811494—
Product(rac)-N-[4-(4-Trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-yl]-methanesulfonamideHCID 7181149315%

Reaction Steps

In analogy to the procedure described for the preparation of (rac)-cyclopropanesulfonic acid [4-(4-trifluoromethyl-phenyl)-6,7-dihydro-5H-[2]pyrindin-7-yl]-amide (example 94), replacing cyclopropanesulfonyl chloride with methanesulfonyl chloride. The title compound was obtained as a light brown oil in 15% yield. MS: 357.4 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09187429B2
Source datasetuspto-grants-2015_11
ORD IDord-312f0e3e673f4fafb3831cfdcd3b90bf
Source noteuspto-grants-2015_11