化工社化工社 化学情報印刷レポート · 研究参考用
4-(Trifluoromethyl)phenylboronic acid → (rac)-4-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Trifluoromethyl)phenylboronic acid | HCID 2734389 | — |
| 反応物 | 4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-OL | HCID 71743891 | — |
| 生成物 | (rac)-4-(4-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-ol | HCID 71811450 | 86% |
反応手順
In analogy to the procedure described for the preparation of example 1 (rac)-4-bromo-5,6,7,8-tetrahydroisoquinolin-8-ol (intermediate A-2) was reacted with 4-(trifluoromethyl)phenylboronic acid to give the title compound as white solid in 86% yield. MS: 294.1 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09187429B2 |
| 出典データセット | uspto-grants-2015_11 |
| ORD ID | ord-2e0647af60c348c7806b27948af4a4b5 |
| 出典メモ | uspto-grants-2015_11 |