HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Trifluoromethyl-6-cyclopropylphenylboronic acid pinacol ester → (R)-N-(4-(2-Cyclopropyl-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Trifluoromethyl-6-cyclopropylphenylboronic acid pinacol ester | HCID 66521282 | — |
| Reactant | (R)-N-(4-Bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide | HCID 86699312 | — |
| Product | (R)-N-(4-(2-Cyclopropyl-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide | HCID 71811448 | 84% |
Reaction Steps
In analogy to the procedure described for the preparation of example 1, (R)—N-(4-bromo-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide (intermediate A-16) was reacted with 4-trifluoromethyl-6-cyclopropylphenylboronic acid pinacol ester acid to give the title compound as colorless oil in 84% yield. MS: 389.2 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187429B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-daf3b7e28c684616a4734ced5f5c8f87 |
| Source note | uspto-grants-2015_11 |