(1,2-Oxazol-4-yl)methanol → HCID 86708035, compound

HRID 714137Notes

Reaction equation

HRID 714137 reaction equation
[S:1]1[C:5]2[CH:6]=[C:7]([S:10]([NH:13][C@H:14]([CH2:45][O:46][Si:47]([C:60]([CH3:63])([CH3:62])[CH3:61])([C:54]3[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=3)[C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)[CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[NH:23][C:24](=[O:44])[C@H:25]([CH:31]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[NH:26][C:27]([O:29][CH3:30])=[O:28])(=[O:12])=[O:11])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[O:64]1[CH:68]=[C:67]([CH2:69]O)[CH:66]=[N:65]1>C(O)CC(C)C>[S:1]1[C:5]2[CH:6]=[C:7]([S:10]([N:13]([CH2:69][C:67]3[CH:66]=[N:65][O:64][CH:68]=3)[C@H:14]([CH2:45][O:46][Si:47]([C:60]([CH3:63])([CH3:62])[CH3:61])([C:54]3[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=3)[C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)[CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[NH:23][C:24](=[O:44])[C@H:25]([CH:31]([C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=3)[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[NH:26][C:27]([O:29][CH3:30])=[O:28])(=[O:12])=[O:11])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 12905097(1,2-Oxazol-4-yl)methanolHCID 86708033HCID 86708033, compound

Product 1

HCID 86708035HCID 86708035, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

The title compound was prepared in 99% yield from intermediate 35 following the procedure described for the step 9 in scheme 1 corresponding to the synthesis of example 1 but using isoxazol-4-ylmethanol instead isoamyl alcohol. MS: m/z=979.3 (MH+).

Workup

  1. customdescribed for the step 9 in scheme 1 corresponding to the synthesis of example 1

Sources & evidence

ORD record
ord-683cfa4bb37348899a35f916bf7d17c6
Source dataset
uspto-grants-2015_11
Patent number
US09187415B2

Reaction notes

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