HRID714137

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12905097

(1,2-Oxazol-4-yl)methanol

C4H5NO2

反应SMILES：COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)NS(=O)(=O)c1ccc2ncsc2c1)C(c1ccccc1)c1ccccc1

HCID86708033

未命名化合物

PRODUCTS

产物

反应SMILES：COC(=O)N[C@H](C(=O)Nc1ccccc1CC[C@@H](CO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)N(Cc1cnoc1)S(=O)(=O)c1ccc2ncsc2c1)C(c1ccccc1)c1ccccc1

HCID86708035

未命名化合物

收率 99%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31260

Isopentyl alcohol

C5H12O

PROCEDURE

实验过程

The title compound was prepared in 99% yield from intermediate 35 following the procedure described for the step 9 in scheme 1 corresponding to the synthesis of example 1 but using isoxazol-4-ylmethanol instead isoamyl alcohol. MS: m/z=979.3 (MH+).

WORKUP

后处理

customdescribed for the step 9 in scheme 1 corresponding to the synthesis of example 1

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-683cfa4bb37348899a35f916bf7d17c6
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US09187415B2
来源说明: uspto-grants-2015_11

反应SMILES

[S:1]1[C:5]2[CH:6]=[C:7]([S:10]([NH:13][C@H:14]([CH2:45][O:46][Si:47]([C:60]([CH3:63])([CH3:62])[CH3:61])([C:54]3[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=3)[C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)[CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[NH:23][C:24](=[O:44])[C@H:25]([CH:31]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[NH:26][C:27]([O:29][CH3:30])=[O:28])(=[O:12])=[O:11])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[O:64]1[CH:68]=[C:67]([CH2:69]O)[CH:66]=[N:65]1>C(O)CC(C)C>[S:1]1[C:5]2[CH:6]=[C:7]([S:10]([N:13]([CH2:69][C:67]3[CH:66]=[N:65][O:64][CH:68]=3)[C@H:14]([CH2:45][O:46][Si:47]([C:60]([CH3:63])([CH3:62])[CH3:61])([C:54]3[CH:55]=[CH:56][CH:57]=[CH:58][CH:59]=3)[C:48]3[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=3)[CH2:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[NH:23][C:24](=[O:44])[C@H:25]([CH:31]([C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=3)[C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[NH:26][C:27]([O:29][CH3:30])=[O:28])(=[O:12])=[O:11])[CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1