Nitrogen → HCID 69671316, compound

Participants

Reaction Steps

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), to a solution of 3,3-difluoropyrrolidine hydrochloride (258 mg, 1.74 mmol) and 2-(2-chloroethoxy)ethanol (3.77 mL, 34.83 mmol) in dry toluene (10 mL) were added K2CO3 (1.32 g, 9.58 mmol) and KI (29 mg, 0.17 mmol). The reaction mixture was stirred at reflux for 2 d. The mixture was cooled down to rt, filtered and concentrated under reduced pressure. The crude residue was purified by FC(CH2Cl2/MeOH/NH4OH, 1:0:0→98:2:0.5) and the title compound obtained as a pale yellow oil.

Provenance & Evidence