HCID 70879987, compound → HCID 95171292, compound

Participants

Reaction Steps

In a flame dried round-bottomed flask equipped with a magnetic stir bar, a suspension of tert-butyl 4-(2-ethoxy-2-oxoethylidene)-3-fluoropiperidine-1-carboxylate (WO2010/056633) (2.17 g, 7.55 mmol) and Pd/C (10% Pd, 217 mg) in dry EtOH (7 mL) was stirred at rt under a H2 atmospheric pressure until completion of the reaction. The mixture was then filtered, washed with EA/EtOH, and the filtrate concentrated under reduced pressure. The crude residue was purified by FC (hept-EA, 6:1) to give cis-tert-butyl 4-(2-ethoxy-2-oxoethyl)-3-fluoropiperidine-1-carboxylate as a pale yellow oil. LC-MS-conditions 08: tR=0.86 min; [M-CH3+H]+=275.32.

Provenance & Evidence