Hydrochloric Acid → 4-(1-Phenylcyclohexyl)butanoic acid

Participants

Reaction Steps

To a solution of ethyl 4-(1-phenylcyclohexyl)butanoate (0.211 g, 0.77 mmol) in MeOH (5 mL) was added 1M sodium hydroxide (1.155 mL, 1.155 mmol) and the mixture was stirred at room temperature for 5 hrs. Then an additional 0.39 ml of 1M NaOH was added and stirring was continued for 3 hrs. To the mixture was added 2 ml of 1N HCl and extracted with EtOAc (2×). The combined extracts were washed with brine, dried over Na2SO4 and evaporated to give an oily residue, which became white solid upon storing at room temperature.

Provenance & Evidence