HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopentanenitrile → 3-(3,5-Difluorophenyl)propane-1,2-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopentanenitrile | HCID 10171288 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | 2-Amino-3-(3,5-difluorophenyl)propanamide | HCID 58247916 | — |
| Product | 3-(3,5-Difluorophenyl)propane-1,2-diamine | HCID 58247787 | 75% |
Reaction Steps
Following the procedure as described in Preparation 11, making variations as required to replace 2-aminopentanenitrile with 2-amino-3-(3,5-difluorophenyl)-propanamide to react with lithium aluminum hydride, 3-(3,5-difluorophenyl)propane-1,2-diamine was obtained as a colorless solid in 75% yield: The crude product was used for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187426B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-4609afaddb47449882cfad8094bf2ced |
| Source note | uspto-grants-2015_11 |