HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluorobenzyl bromide → methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluorobenzyl bromide | HCID 68021 | — |
| Reactant | methyl 2-(5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate | HCID 58247755 | — |
| Reactant | 2-(2-Oxoimidazolidin-1-yl)isonicotinate | HCID 86653051 | — |
| Product | methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate | HCID 58247815 | 65% |
Reaction Steps
Following the procedure as described in Preparation 17, making variations as required to replace 2-(2-oxoimidazolidin-1-yl)isonicotinate with methyl 2-(5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate to react with 1-(bromomethyl)-4-fluorobenzene, methyl 2-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)isonicotinate was obtained as a colorless solid in 65% yield: MS (ES+) m/z 328.9 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187426B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-2f75310ec1854f20b67a90b0eaf1a1b6 |
| Source note | uspto-grants-2015_11 |