反应详情

Following the procedure as described in Preparation 17, making variations as required to replace 1-(bromomethyl)-4-fluorobenzene with 4-(bromomethyl)-1,2-difluorobenzene to react with 2-(2-oxoimidazolidin-1-yl)isonicotinate, methyl 2-(3-(3,4-difluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinate was obtained as a colorless solid in 66% yield: 1H NMR (300 MHz, CDCl3) δ 8.86-8.85 (m, 1H), 8.37 (dd, J=5.1, 0.6 Hz, 1H), 7.47-7.45 (m, 1H), 7.16-7.01 (m, 3H), 4.43 (s, 2H), 4.05 (t, J=8.0 Hz, 2H), 3.92 (s, 3H), 3.38 (t, J=8.0 Hz, 2H); MS (ES+) m/z 348.0 (M+1).

1. customas described in Preparation 17