4-Fluorobenzyl bromide → HCID 58247794, compound

Participants

Reaction Steps

Following the procedure as described in Preparation 17, making variations as required to replace 1-(bromomethyl)-4-fluorobenzene with 1-(bromomethyl)-2,4-difluorobenzene to react with 2-(2-oxoimidazolidin-1-yl)isonicotinate, methyl 2-(3-(2,4-difluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinate was obtained as a colorless solid in 64% yield: 1H NMR (300 MHz, CDCl3) δ 8.85 (s, 1H), 8.36 (d, J=5.1 Hz, 1H), 7.46-7.31 (m, 2H), 6.89-6.79 (m, 2H), 4.51 (s, 2H), 4.04 (t, J=8.1 Hz, 2H), 3.92 (s, 3H), 3.44 (t, J=8.1 Hz, 2H); MS (ES+) m/z 347.9 (M+1).

Provenance & Evidence