4-(Trifluoromethyl)benzylamine → 2-benzamido-N-(3,5-dichlorobenzyl)isonicotinamide

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations as required to replace (4-(trifluoromethyl)phenyl)methanamine with (3,5-dichlorophenyl)-methanamine to react with 2-benzamidoisonicotinic acid, 2-benzamido-N-(3,5-dichlorobenzyl)isonicotinamide was obtained as a colorless solid in 41% yield: mp 248-251° C. (dichloromethane/hexanes); 1H NMR (300 MHz, DMSO-d6) δ 11.01 (br s, 1H), 9.42 (br s, 1H), 8.63-8.54 (m, 2H), 8.06 (s, 2H), 7.60-7.39 (m, 7H), 4.53-4.51 (d, J=4.5 Hz, 2H).

Provenance & Evidence