4-(Trifluoromethyl)benzylamine → 2-benzamido-N-[2-(2-chlorophenyl)ethyl]-isonicotinamide

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations as required to replace (4-(trifluoromethyl)phenyl)methanamine with 2-(2-chlorophenyl)ethanamine to react with 2-benzamidoisonicotinic acid, 2-benzamido-N-[2-(2-chlorophenyl)ethyl]-isonicotinamide was obtained as a colorless solid in 27% yield: 1H NMR (300 MHz, DMSO-d6) δ 10.91-10.82 (m, 1H), 8.91-8.85 (m, 1H), 8.56-8.44 (m, 2H), 8.06-7.98 (m, 2H), 7.63-7.17 (m, 8H), 3.55-3.48 (m, 2H), 3.03-2.92 (m, 2H); MS (ES+) m/z 380.5 (M+1), 382.3 (M+2).

Provenance & Evidence