4-(Trifluoromethyl)benzylamine → HCID 67153853, compound

HRID 714307Notes

Reaction equation

HRID 714307 reaction equation
FC(F)(F)C1C=CC(CN)=CC=1.[F:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[CH2:20][CH2:21][NH2:22].[C:23]([NH:31][C:32]1[CH:33]=[C:34]([CH:38]=[CH:39][N:40]=1)[C:35](O)=[O:36])(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[C:23]([NH:31][C:32]1[CH:33]=[C:34]([CH:38]=[CH:39][N:40]=1)[C:35]([NH:22][CH2:21][CH2:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[F:13])=[O:36])(=[O:30])[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

4

Reactant 3

HCID 768044-(Trifluoromethyl)benzylamineHCID 6433572-(2-Fluorophenyl)ethylamineHCID 643938512-Benzamidoisonicotinic acid

Product 1

HCID 67153853HCID 67153853, compound

Procedure

Following the procedure as described in Example 1, making variations as required to replace (4-(trifluoromethyl)phenyl)methanamine with 2-(2-fluorophenyl)ethanamine to react with 2-benzamidoisonicotinic acid, 2-benzamido-N-[2-(2-fluorophenyl)ethyl]-isonicotinamide was obtained as a colorless 2H), 3.00 (t, J=7.0 Hz, 2H); MS (ES+) m/z 364.6 (M+1).

Sources & evidence

ORD record
ord-b901ac0ecd5b47efad5018b1850f5fec
Source dataset
uspto-grants-2015_11
Patent number
US09187426B2

Reaction notes

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