3-Methoxyphenethylamine → HCID 67153852, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations as required to replace (4-(trifluoromethyl)phenyl)methanamine with 2-(3-methoxyphenyl)ethanamine to react with 2-benzamidoisonicotinic acid, 2-benzamido-N-[2-(3-methoxyphenyl)ethyl]isonicotinamide was obtained as a colorless solid in 45% yield: 1H NMR (300 MHz, DMSO-d6) δ 10.98 (s, 1H), 8.88 (t, J=5.5 Hz, 1H), 8.57 (s, 1H), 8.52-8.49 (m, 1H), 8.07-8.04 (m, 2H), 7.63-7.48 (m, 4H), 7.24-7.17 (m, 1H), 6.84-6.76 (m, 3H), 3.73 (s, 3H), 3.55-3.48 (m, 2H), 2.85 (t, J=7.3 Hz, 2H); MS (ES+) m/z 376.5 (M+1).

Provenance & Evidence