O-Methyltyramine → HCID 67153833, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations as required to replace (4-(trifluoromethyl)phenyl)methanamine with 2-(4-methoxyphenyl)ethanamine to react with 2-benzamidoisonicotinic acid, 2-benzamido-N-[2-(4-methoxyphenyl)ethyl]isonicotinamide was obtained as a colorless solid in 48% yield: 1H NMR (300 MHz, CDCl3) δ 8.79 (s, 1H), 7.91 (d, J=5.6 Hz, 2H), 7.62-7.43 (m, 4H), 7.19-7.15 (m, 4H), 6.90-6.87 (m, 2H), 6.45-6.43 (m, 1H), 3.79 (s, 3H), 3.71-3.65 (m, 2H), 2.89 (t, J=7.2 Hz, 2H); MS (ES+) m/z 376.5 (M+1).

Provenance & Evidence