2-(4-Chlorophenyl)ethylamine → HCID 67153807, compound

Participants

Reaction Steps

Following the procedure as described in Example 1, making variations as required to replace (4-(trifluoromethyl)phenyl)methanamine with 2-(4-chlorophenyl)ethanamine to react with 2-benzamidoisonicotinic acid, 2-benzamido-N-[2-(4-chlorophenyl)ethyl]isonicotinamide was obtained as a colorless solid in 52% yield: 1H NMR (300 MHz, DMSO-d6) δ 10.97 (s, 1H), 8.82-8.05 (m, 1H), 8.54-8.49 (m, 2H), 8.06-8.04 (m, 2H), 7.63-7.46 (m, 4H), 7.38-7.27 (m, 4H), 3.51-3.49 (m, 2H), 2.86 (t, J=7.1 Hz, 2H); MS (ES+) m/z 380.4 (M+1), 382.3 (M+2).

Provenance & Evidence