2-Fluorobenzoyl chloride → HCID 67153864, compound

Participants

Reaction Steps

Following the procedure as describe in Example 6, making variations as required to replace 2-fluorobenzoyl chloride with 3,5-difluorobenzoyl chloride to react with 2-amino-N-benzylisonicotinamide, N-benzyl-2-(3,5-difluorobenzamido)isonicotinamide was obtained as a colorless solid in 68% yield: mp 185-187° C. (hexanes/ethyl acetate); 1H NMR (300 MHz, CDCl3) δ 11.16 (s, 1H), 9.35 (t, J=6.0 Hz, 1H), 8.54-8.50 (m, 2H), 7.75-7.71 (m, 2H), 7.58-7.47 (m, 2H), 7.31-7.21 (m, 5H), 4.46 (d, J=5.9 Hz, 2H); MS (ES+) m/z 368.5 (M+1).

Provenance & Evidence