2-Fluorobenzoyl chloride → HCID 67153850, compound

Participants

Reaction Steps

Following the procedure as describe in Example 6, making non-critical variations as required to replace 2-fluorobenzoyl chloride with 3-(trifluoromethyl)benzoyl chloride to react with 2-amino-N-benzylisonicotinamide, N-benzyl-2-(3-(trifluoromethyl)benzamido)-isonicotinamide was obtained as a colorless solid in 80% yield: mp 126-128° C.; 1H NMR (300 MHz, CDCl3) δ 10.36 (s, 1H), 8.82 (s, 1H), 8.41-8.14 (m, 4H), 7.95-7.27 (m, 7H), 7.03 (s, 1H), 4.57 (d, J=5.1 Hz, 2H); MS (ES+) m/z 400.5 (M+1).

Provenance & Evidence