2-Fluorobenzoyl chloride → HCID 67153850, compound

Participants

Reaction Steps

Following the procedure as describe in Example 6, making variations as required to replace 2-fluorobenzoyl chloride with 2-(trifluoromethyl)benzoyl chloride to react with 2-amino-N-benzylisonicotinamide, N-benzyl-2-(3-(trifluoromethyl)benzamido)-isonicotinamide was obtained as a colorless solid in 73% yield: mp 87-88° C.; 1H NMR (300 MHz, CDCl3) δ 10.09 (s, 1H), 8.58 (s, 1H), 7.82-6.95 (m, 12H), 4.57 (d, J=5.1 Hz, 2H); MS (ES+) m/z 400.5 (M+1).

Provenance & Evidence