Propylenediamine → HCID 178521771, compound

HRID 714341Notes

Reaction equation

HRID 714341 reaction equation
NCC(N)C.[C:6]1([CH:12]([NH2:15])[CH2:13][NH2:14])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[C:16]([NH:24][C:25]1[CH:26]=[C:27]([CH:31]=[CH:32][N:33]=1)[C:28](O)=O)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:6]1([CH:12]2[CH2:13][NH:14][C:28]([C:27]3[CH:31]=[CH:32][N:33]=[C:25]([NH:24][C:16](=[O:23])[C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:26]=3)=[N:15]2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

4

Reactant 3

HCID 6567PropylenediamineHCID 4320111-Phenylethane-1,2-diamineHCID 643938512-Benzamidoisonicotinic acid

Product 1

HCID 178521771HCID 178521771, compoundYield 17%

Procedure

Following the procedure as described in Example 9, making variations as required to replace 1,2-diaminopropane with 1-phenylethane-1,2-diamine to react with 2-benzamidoisonicotinic acid, N-(4-(4-phenyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide was obtained in 17% yield: MS (ES+) m/z 343.3 (M+1).

Sources & evidence

ORD record
ord-8cb4dda379714be8bbb3e3a43a45cff4
Source dataset
uspto-grants-2015_11
Patent number
US09187426B2

Reaction notes

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