反应详情

Following the procedure as described in Example 10, making variations as required to replace N-(4-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide with N-(4-(4-benzyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide, N-(4-(4-benzyl-1H-imidazol-2-yl)pyridin-2-yl)benzamide was obtained as a colorless solid in 19% yield: mp 110-112° C.; 1H NMR (300 MHz, CDCl3) δ 8.96 (br s, 1H), 8.62 (s, 1H), 8.18 (d, J=3.7 Hz, 1H), 7.83 (d, J=7.2 Hz, 2H), 7.70 (d, J=4.8 Hz, 1H), 7.58-7.50 (m, 1H), 7.48-7.40 (m, 2H), 7.30-7.14 (m, 5H), 6.81 (br s, 1H), 3.96 (s, 2H); MS (ES+) m/z 355.3 (M+1).