反应详情

Following the procedure as described in Example 10, making non-critical variations as required to replace N-(4-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide with N-(4-(4-isobutyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide, N-(4-(4-isobutyl-1H-imidazol-2-yl)pyridin-2-yl)benzamide was obtained as a colorless solid in 36% yield: mp 103-105° C.; 1H NMR (300 MHz, CDCl3) δ 9.07 (br s, 1H), 8.68 (s, 1H), 8.17 (d, J=5.2 Hz, 1H), 7.86 (d, J=7.3 Hz, 2H), 7.73 (d, J=5.3 Hz, 1H), 7.59-7.40 (m, 3H), 6.89 (s, 1H), 2.45 (d, J=7.1 Hz, 2H), 1.98-1.79 (m, 1H), 0.90 (d, J=6.6 Hz, 6H); MS (ES+) m/z 321.3 (M+1).