HCID 178430407, compound → HCID 178521772, compound

Participants

Reaction Steps

Following the procedure as described in Example 10, making variations as required to replace N-(4-(4-methyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide with N-(4-(4-phenyl-4,5-dihydro-1H-imidazol-2-yl)pyridin-2-yl)benzamide, N-(4-(4-phenyl-1H-imidazol-2-yl)pyridin-2-yl)benzamide was obtained as a colorless solid in 13% yield: mp 265-267° C.; 1H NMR (300 MHz, DMSO-d6) δ 13.14 (br s, 1H), 10.88 (br s, 1H), 8.81 (s, 1H), 8.47 (d, J=5.2 Hz, 1H), 8.10-8.05 (m, 2H), 7.93-7.88 (m, 2H), 7.72 (dd, J=5.2, 1.5 Hz, 1H), 7.65-7.36 (m, 6H), 7.28-7.21 (m, 1H); 13C NMR (75 MHz, DMSO-d6) δ 165.9, 152.8, 148.5, 143.6, 141.9, 139.1, 134.1, 134.0, 131.9, 128.5, 128.4, 127.9, 126.5, 124.5, 115.8, 115.2, 110.0; MS (ES+) m/z 341.3 (M+1).

Provenance & Evidence