反应详情

Following the procedure as described in Example 14, making variations as required to replace oxazol-4-ylmethanamine with thiazol-2-ylmethanamine to react with 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinic acid, 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(thiazol-2-ylmethyl)isonicotinamide was obtained as a colorless solid in 88% yield: mp 123-125° C.; NMR (300 MHz, CDCl3) δ 8.64 (s, 1H), 8.35 (d, J=5.1 Hz, 1H), 7.70 (d, J=2.7 Hz, 1H), 7.39-7.21 (m, 5H), 7.04-6.99 (m, 2H), 4.93 (d, J=5.7 Hz, 2H), 4.42 (s, 2H), 4.02 (t, J=8.1 Hz, 2H), 3.36 (t, J=8.1 Hz, 2H); MS (ES+) m/z 411.9 (M+1).