Oxazol-2-ylmethanamine → 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(oxazol-2-ylmethyl)isonicotinamide

Participants

Reaction Steps

Following the procedure as described in Example 14, making variations as required to replace oxazol-4-ylmethanamine with oxazol-2-ylmethanamine to react with 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinic acid, 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(oxazol-2-ylmethyl)isonicotinamide was obtained as a colorless solid in 49% yield: mp 148-150° C.; 1H NMR (300 MHz, DMSO-d6) δ 9.36 (t, J=5.7 Hz, 1H), 8.60 (s, 1H), 8.38 (d, J=5.1 Hz, 2H), 8.03 (s, 1H), 7.36-7.31 (m, 3H), 7.18-7.07 (m, 2H), 4.55 (d, J=5.7 Hz, 2H), 4.39 (s, 2H), 3.94 (t, J=8.1 Hz, 2H), 3.45 (t, J=8.0 Hz, 2H); MS (ES+) m/z 396.0 (M+1).

Provenance & Evidence