(1-methyl-1H-pyrazol-4-yl)methanamine → HCID 44552745, compound

Participants

Reaction Steps

Following the procedure as described in Example 14, making variations as required to replace oxazol-4-ylmethanamine with (1-methyl-1H-pyrazol-4-yl)methanamine to react with 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinic acid, 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl)methyl)isonicotinamide was obtained as a colorless solid in 23% yield: mp 165-166° C.; 1HNMR (300 MHz, CDCl3) δ 8.52 (s, 1H), 8.34 (d, J=5.1 Hz, 1H), 7.44-7.37 (m, 3H), 7.27-7.22 (m, 2H), 7.04-6.98 (m, 2H), 6.70 (br s, 1H), 4.45-4.41 (m, 4H), 4.03 (t, J=8.1 Hz, 2H), 3.84 (s, 3H), 3.36 (t, J=8.1 Hz, 2H); 13C NMR (75 MHz, CDCl3) δ 165.5, 164.0, 160.7, 157.0, 152.9, 148.2, 143.0, 138.9, 132.1, 132.0, 129.9, 129.8, 116.0, 115.9, 115.6, 109.0, 47.2, 41.3, 41.0, 39.0, 34.5; MS (ES+) m/z 408.9 (M+1).

Provenance & Evidence