1-(1,5-Dimethyl-1H-pyrazol-3-yl)methanamine → HCID 44552748, compound

Participants

Reaction Steps

Following the procedure as described in Example 14, making variations as required to replace oxazol-4-ylmethanamine with (1,5-dimethyl-1H-pyrazol-3-yl)methanamine to react with 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinic acid, N-((1,5-dimethyl-1H-pyrazol-3-yl)methyl)-2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinamide was obtained as a colorless solid in 70% yield: mp 150-152° C.; 1H NMR (300 MHz, CDCl3) δ 8.57 (s, 1H), 8.33 (d, J=5.1 Hz, 1H), 7.38-7.36 (m, 1H), 7.28-7.23 (m, 2H), 7.05-6.97 (m, 2H), 6.87 (br s, 1H), 5.98 (s, 1H), 4.53 (d, J=5.1 Hz, 2H), 4.42 (s, 2H), 4.02 (t, J=8.1 Hz, 2H), 3.71 (s, 3H), 3.35 (t, J=8.1 Hz, 2H), 2.21 (s, 3H); MS (ES+) m/z 422.9 (M+1).

Provenance & Evidence