(2-Methylthiazol-4-yl)MethanaMine → 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((2-methylthiazol-4-yl)methyl)isonicotinamide

Participants

Reaction Steps

Following the procedure as described in Example 14, making variations as required to replace oxazol-4-ylmethanamine with (2-methylthiazol-4-yl)methanamine to react with 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinic acid, 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((2-methylthiazol-4-yl)methyl)isonicotinamide was obtained as a colorless solid in 26% yield: mp 76-78° C.; 1H NMR (300 MHz, CDCl3) δ 8.60 (d, J=0.6 Hz, 1H), 8.34 (d, J=5.7 Hz, 1H), 7.36 (dd, J=5.4, 1.5 Hz, 1H), 7.28-7.24 (m, 2H), 7.05-6.99 (m, 4H), 4.66 (d, J=5.7 Hz, 2H), 4.43 (s, 2H), 4.03 (t, J=8.1 Hz, 2H), 3.36 (t, J=8.1 Hz, 2H), 2.68 (s, 3H); MS (ES+) m/z 425.8 (M+1).

Provenance & Evidence