Isoxazol-3-ylmethanamine → HCID 44552915, compound

Participants

Reaction Steps

Following the procedure as described in Example 14, making variations as required to replace oxazol-4-ylmethanamine with isoxazol-3-ylmethanamine to react with 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinic acid, 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(isoxazol-3-ylmethyl)isonicotinamide was obtained as a colorless solid in 53% yield: mp 127-129° C.; 1H NMR (300 MHz, CDCl3) δ 8.61 (s, 1H), 8.37-8.34 (m, 2H), 7.36 (dd, J=5.1 Hz, 1.2 Hz, 1H), 7.31-7.23 (m, 2H), 7.04-6.98 (m, 3H), 6.39 (d, J=1.5 Hz, 1H), 4.73 (d, J=6.0 Hz, 2H), 4.42 (s, 2H), 4.03 (t, J=8.1 Hz, 2H), 3.36 (t, J=8.1 Hz, 2H); MS (ES+) m/z 395.7 (M+1).

Provenance & Evidence