(4-methyl-2-phenyl-1,3-thiazol-5-yl)methanamine → HCID 44552917, compound

Participants

Reaction Steps

Following the procedure as described in Example 14, making variations as required to replace oxazol-4-ylmethanamine with (4-methyl-2-phenylthiazol-5-yl)methanamine to react with 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinic acid, 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-((4-methyl-2-phenylthiazol-5-yl)methyl)isonicotinamide was obtained as a colorless solid in 53% yield: mp 182-184° C.; 1HNMR (300 MHz, CDCl3) δ 8.57 (s, 1H), 8.36 (d, J=5.7 Hz, 1H), 7.87-7.84 (m, 2H), 7.42-7.37 (m, 4H), 7.24-7.20 (m, 2H), 7.03-6.93 (m, 3H), 4.75 (d, J=5.7 Hz, 2H), 4.40 (s, 2H), 4.02 (t, J=8.1 Hz, 2H), 3.35 (t, J=8.1 Hz, 2H), 2.49 (s, 3H); 13C NMR (75 MHz, CDCl3) δ 166.1, 165.6, 164.0, 160.7, 157.0, 153.0, 151.1, 148.5, 142.4, 133.6, 132.0, 129.9, 129.8, 128.9, 127.7, 126.4, 116.0, 115.8, 115.6, 109.0, 47.2, 41.3, 41.0, 35.8, 15.3; MS (ES+) m/z 501.9 (M+1).

Provenance & Evidence