反应详情

Following the procedure as described in Example 15, making variations as required to replace benzylamine with pyridin-3-ylmethanamine to react with methyl 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinate, 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-3-ylmethyl)isonicotinamide was obtained as a colorless solid in 39% yield: mp 153-155° C.; 1H NMR (300 MHz, DMSO-d6) δ 9.29 (br, 1H), 8.60 (s, 1H), 8.52 (d, J=2.1 Hz, 1H), 8.44-8.42 (m, 1H), 8.37 (d, J=5.4 Hz, 1H), 7.71-7.68 (m, 1H), 7.35-7.31 (m, 4H), 7.18-7.13 (m, 2H), 4.46 (d, J=6.0 Hz, 2H), 4.39 (s, 2H), 3.93 (t, J=7.5 Hz, 2H), 3.38-3.34 (m, 2H); 13C NMR (75 MHz, CDCl3) δ 165.8, 156.8, 153.5, 149.3, 148.7, 148.5, 143.2, 135.7, 135.1, 133.6, 133.6, 130.4, 130.3, 124.0, 116.0, 115.7, 115.2, 110.4, 46.6, 41.6, 41.2, 41.0; MS (ES+) m/z 406.2 (M+1).