反应详情

Following the procedure as described in Example 15, making variations as required to replace benzylamine with pyridin-4-ylmethanamine to react with methyl 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinate, 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-4-ylmethyl)isonicotinamide was obtained as a colorless solid in 42% yield: mp 205-207° C.; 1H NMR (300 MHz, DMSO-d6) δ 9.33 (t, J=6.0 Hz, 1H), 8.62 (s, 1H), 8.49-8.47 (m, 2H), 8.39 (d, J=5.4 Hz, 1H), 7.37-7.26 (m, 5H), 7.18-7.13 (m, 2H), 4.47 (d, J=5.7 Hz, 2H), 4.39 (s, 2H), 3.94 (t, J=7.5 Hz, 2H), 3.38-3.32 (m, 2H); 13C NMR (75 MHz, DMSO-d6) δ 165.9, 160.4, 156.8, 153.6, 150.1, 148.6, 143.1, 133.6, 133.6, 130.4, 130.3, 122.6, 116.0, 115.7, 115.2, 110.4, 46.6, 42.3, 41.6, 41.2; MS (ES+) m/z 406.0.