Benzylamine → N-(4-fluorobenzyl)-2-(2-oxo-3-(pyridin-2-ylmethyl)imidazolidin-1-yl)isonicotinamide

Participants

Reaction Steps

Following the procedure as described in Example 15, making variations as required to replace benzylamine with 4-fluorobenzylamine to react with methyl 2-(2-oxo-3-(pyridin-2-ylmethyl)imidazolidin-1-yl)isonicotinate, the title compound was obtained as a colorless solid in 52% yield: mp 141-142° C.; 1H NMR (300 MHz, CDCl3) δ 8.56-8.53 (m, 2H), 8.35 (d, J=4.8 Hz, 1H), 7.68-6.86 (m, 9H), 4.57-4.54 (m, 4H), 4.06 (t, J=7.9 Hz, 2H), 3.53 (t, J=8.0 Hz, 2H); MS (ES+) m/z 405.7 (M+1).

Provenance & Evidence