4-Fluorobenzylamine → HCID 44553615, compound

Participants

Reaction Steps

Following the procedure as described in Example 15, making variations as required to replace methyl 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinate with methyl 2-(3-(2,4-difluorobenzyl)-2-oxoimidazolidin-1-yl)isonicotinate to react with 4-fluorobenzylamine, 2-(3-(2,4-difluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(4-fluorobenzyl)isonicotinamide was obtained as a colorless solid in 55% yield: mp 171-173° C.; 1H NMR (300 MHz, CDCl3) δ 8.61 (s, 1H), 8.36 (dd, J=5.1, 0.6 Hz, 1H), 7.56-7.27 (m, 4H), 7.07-6.97 (m, 2H), 6.92-6.74 (m, 3H), 4.58 (d, J=6.0 Hz, 2H), 4.48 (s, 2H), 4.04 (t, J=8.1 Hz, 2H), 3.43 (t, J=8.1 Hz, 2H); MS (ES+) m/z 441.1 (M+1).

Provenance & Evidence