HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 714440Generated: October 31, 2026
4-Hydroxybenzaldehyde → 4-[(1R)-2-Hydroxy-1-methylethoxy]benzaldehyde
https://huagongshe.com/reaction/714440
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | (S)-(+)-2-Chloro-1-propanol | HCID 641045 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-[(1R)-2-Hydroxy-1-methylethoxy]benzaldehyde | HCID 86691912 | — |
Reaction Steps
Under argon, 785 mg (6.43 mmol) of 4-hydroxybenzaldehyde and 759 mg (8.04 mmol) of (S)-(+)-2-chloro-1-propanol were initially charged in 15.7 ml of DMF. 2.04 g (19.3 mmol) of sodium carbonate were added, and the mixture was then stirred at 130° C. for 20 h. The reaction mixture was purified by preparative HPLC (Chromasil, water/acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09187428B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-6432292a88c94a6c8658ff6dbbe8af02 |
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| Source note | uspto-grants-2015_11 |
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