Hydrochloric Acid → HCID 178510476, compound

Participants

Reaction Conditions

Reaction Steps

2 g (5.77 mmol) of 2-amino-4-(3-fluorophenyl)-6-(phenylsulfanyl)pyridine-3,5-dicarbonitrile (Example 37A) were initially charged in 20 ml of DMF. 1.58 g (20.21 mmol) of sodium sulfide were added, and the mixture was stirred at 80° C. for 2 h and stirred further at RT overnight. 10 ml of 1N hydrochloric acid were added to the reaction mixture, and the precipitate was filtered off, washed with water and dried under high vacuum. In addition, more solid precipitated from the filtrate overnight, and this solid was filtered off and washed with water. Once more, this gave the desired solid.

Provenance & Evidence