Hydrochloric Acid → HCID 178510369, compound

Participants

Reaction Conditions

Reaction Steps

918 mg (2.928 mmol) of 4-phenyl-2-(phenylsulfanyl)pyridine-3,5-dicarbonitrile (Example 36A) were initially charged in 10.7 ml of DMF. 274 mg (3.514 mmol) of sodium sulfide were added, and the reaction solution was then stirred at 80° C. for 3 h, and after 1.5 h another 274 mg (3.514 mmol) of sodium sulfide were added. The mixture was stirred at RT overnight. 5.85 ml of 1N hydrochloric acid were added to the reaction mixture, and the reaction solution was evaporated. 5 ml of tetrahydrofuran were added to the residue, and the precipitate formed was filtered off and discarded. The filtrate was purified by preparative HPLC (Chromasil, water/acetonitrile).

Provenance & Evidence