Hydrochloric Acid → HCID 178488665, compound

Participants

Reaction Conditions

Reaction Steps

1.3 g (3.028 mmol) of 4-(4-methoxyphenyl)-2-(phenylsulfanyl)pyridine-3,5-dicarbonitrile (Example 48A) were initially charged in 11 ml of DMF. 284 mg (3.634 mmol) of sodium sulfide were added, and the mixture was then stirred at 80° C. for 2 h and stirred further at RT overnight. 6 ml of 1N hydrochloric acid were added to the reaction mixture, and the reaction solution was evaporated. The residue was purified by preparative HPLC (Chromasil, water/acetonitrile).

Provenance & Evidence