反应详情

7.50 g (33.989 mmol) of 4-(hydroxymethyl)-N-methylpyridine-2-carboxamide hydrochloride hydrate (Example 40A) were initially charged in 90 ml of methanol, 23.64 g (271.915 mmol) of manganese dioxide were added and the mixture was stirred at RT overnight. The reaction mixture was filtered off with suction through silica gel, the silica gel/manganese dioxide mixture was stirred with tetrahydrofuran/methanol 1:1 overnight, the silica gel/manganese dioxide mixture was then filtered off and the filtrate was evaporated.

1. filtrationThe reaction mixture was filtered off with suction through silica gel
2. stirringthe silica gel/manganese dioxide mixture was stirred with tetrahydrofuran/methanol 1:1 overnight
3. filtrationthe silica gel/manganese dioxide mixture was then filtered off
4. customthe filtrate was evaporated