Hydrochloric Acid → HCID 86691916, compound

Participants

Reaction Conditions

Reaction Steps

1.72 g (4.3 mmol) of 3-{[(6-amino-3,5-dicyano-4-phenylpyridin-2-yl)sulfanyl]methyl}-N-methylbenzenecarboxamide Example 9 were dissolved in ice-cooled conc. hydrochloric acid. 0.89 g (12.89 mmol) of sodium nitrite was added, and the mixture was then stirred at 0° C. for 1 h and at RT overnight. After 1 h, a precipitate had already formed. With cooling, 100 ml of water were added to the reaction mixture, and the pH was adjusted carefully to pH 7 using conc. aqueous sodium hydroxide solution. The precipitate was filtered off.

Provenance & Evidence