HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → rac-N-[3-(1-Chloroethyl)phenyl]methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | [3-(Hydroxyethyl)phenyl](methylsulfonyl)amine | HCID 43508614 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | rac-N-[3-(1-Chloroethyl)phenyl]methanesulfonamide | HCID 66631452 | — |
Reaction Steps
650 mg (3.02 mmol) of rac-N-[3-(1-hydroxyethyl)phenyl]methanesulfonamide (Example 87A) were initially charged in 9 ml of dichloromethane. At 0° C., 1.08 g (9.07 mmol) of thionyl chloride were added dropwise, and the reaction solution was stirred at RT for 3 h. The reaction solution was evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187428B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-36efb641713d4d08a92ccf1df021da00 |
| Source note | uspto-grants-2015_11 |