Hydrochloric Acid → HCID 56592009, compound

Participants

Reaction Steps

85 mg (0.179 mmol) of rac-methyl 3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)ethyl]benzenecarboxylate (Example 62A) were dissolved in 4 ml of tetrahydrofuran. 8.58 mg (0.358 mmol) of lithium hydroxide were added, and the mixture was then stirred at RT overnight. The reaction solution was adjusted to pH 4 using 1N hydrochloric acid and extracted three times with ethyl acetate. The combined organic phases were dried over magnesium sulfate, filtered and evaporated.

Provenance & Evidence