HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | Methyl 4-(2-ethoxy-2-oxoethyl)-3-methylbenzoate | HCID 67365879 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-(Methoxycarbonyl)-2-methylphenyl)acetic acid | HCID 57555224 | 91.5% |
Reaction Steps
Methyl 4-(2-ethoxy-2-oxoethyl)-3-methylbenzoate (366 mg) was suspended in MeOH(10 ml) and H2O (2 ml) and treated with LiOH (48 mg) over 3 days. After the reaction mixture was acidified with 1N HCl, the product was extracted with EtOAc. Evaporation and drying in vacuum afforded the desired product (295 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09187447B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-13c55a5b75694ab0bd94317153354e56 |
| Source note | uspto-grants-2015_11 |