tert-Butanol → HCID 71536481, compound

HRID 714561Notes

Reaction equation

HRID 714561 reaction equation
[O:1]1[CH2:3][CH:2]1[CH2:4][N:5]1[C:18]2[CH:17]=[C:16]([C:19]([F:22])([F:21])[F:20])[CH:15]=[CH:14][C:13]=2[S:12][C:11]2[C:6]1=[CH:7][CH:8]=[CH:9][CH:10]=2.CC(O)(C)C.[NH:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>>[O:31]1[CH2:32][CH2:33][N:28]([CH2:3][CH:2]([OH:1])[CH2:4][N:5]2[C:18]3[CH:17]=[C:16]([C:19]([F:21])([F:20])[F:22])[CH:15]=[CH:14][C:13]=3[S:12][C:11]3[C:6]2=[CH:7][CH:8]=[CH:9][CH:10]=3)[CH2:29][CH2:30]1

Participants

4

Reactant 3

HCID 6386tert-ButanolHCID 8083MorpholineHCID 86731037HCID 86731037, compound

Product 1

HCID 71536481HCID 71536481, compound

Procedure

Utilizing the procedure outline in Example 1, Step 2, (±)-10-(oxiran-2-ylmethyl)-2-(trifluoromethyl)-10H-phenothiazine and 2-methyl-2-propanol (127 mg, 0.39 mmol) was reacted with morpholine (41 μL, 0.48 mmol) to afford the title compound. LCMS m/z 411 (M+H)

Sources & evidence

ORD record
ord-740054e5ac6a48f0af4e3ea9449ed14c
Source dataset
uspto-grants-2015_11
Patent number
US09187439B2

Reaction notes

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