Methyl {3-(4-chlorophenyl)-5-oxo-4-[(1E)-3,3,3-trifluoroprop-1-en-1-yl]-4,5-dihydro-1H-1,2,4-triazol-1-yl}acetate → Methyl [3-(4-chlorophenyl)-5-oxo-4-(3,3,3-trifluoropropyl)-4,5-dihydro-1H-1,2,4-triazol-1-yl]acetate

Participants

Reaction Steps

1.3 g (3.59 mmol) of the compound from Example 9A and 150 mg of platinum on carbon (5%) were dissolved in 150 ml of methanol and hydrogenated at atmospheric pressure for 18 h. For work-up, the catalyst was filtered off through kieselguhr and the filtrate was concentrated on a rotary evaporator. Drying of the residue under high vacuum gave 1.26 g (89% of theory) of the title compound of a purity of 92%.

Provenance & Evidence