Pyridine → HCID 53419305, compound

Participants

Reaction Steps

400 mg (2.85 mmol) of ethyl 1H-pyrazole-4-carboxylate, 893 mg (5.71 mmol) of 2-chlorophenyl-boronic acid, 100 mg of 3 Å molecular sieve and 778 mg (4.28 mmol) of copper(II) acetate were initially charged in 2 ml of dichloromethane, and 461 μl (5.71 mmol) of pyridine were added. The mixture was stirred at RT for 20 h. For work-up, the mixture was filtered through a little kieselguhr, the filter residue was rinsed with about 10 ml of dichloromethane and the combined filtrates were concentrated under reduced pressure. The crude product was purified by chromatography on silica gel (mobile phase: cyclohexane/ethyl acetate 10:1, then 5:1). This gave 71 mg (10% of theory) of the target compound.

Provenance & Evidence